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It is based on a simple premise that you would not have eaten the Paleo Diet if the cavemen hadn't eaten it. That is the reason that the Paleo Diet is also known as "The Cavemen Diet". It includes nuts, meats, fish, seeds and vegetables, all those things which you could find or hunt from the natural environment. So it is the diet which our great ancestors ate and used to live a healthy life. As time goes on, people became more advanced, and the agricultural revolution took place. We became farmers from hunters. We formed societies. And from that day we have progressed to what we are today.

Our diet also shifted with the time being from Paleo to more modern which increased intake of calories. And there the problem took place. As according to Robb Wolf, Homo-Sapiens in old age spent a very long time as hunters and made their bodies adapts that way of living over thousands of years, but as the revolution took place it shifted our diet but our genetics are the same as the past Homo-Sapiens, so our bodies never synced properly to eating the food what we are eating right now. We started relying on grains like pasta, bread, corn, rice etc and nearly ceased the intake of vegetables, seasonal fruits and meat. Hence becoming fatter and exposed to diseases like diabetes and heart attacks. According to study about 33% of us are considered as obese and 66% of us are overweight, and it is getting worse day by day. The average Homo-Sapien back then was big, strong, muscular, lively, athletic, adaptable and in good shape. But now an average Homo-Sapien is obese, overweight, out of shape, worried, sleep deprived, sorrowful and dying from countless preventable diseases.
So it is obvious that our modern diet (like grains) is not healthy for us as we are not biologically designed for it, and it is better to take that diet which allows us to tap into our genetic potential and makes us start living healthier. One more point was raised by Mr. Mark in his article from Daily Apple that grains cause kind of weird reaction in our digestive system.
Basically, grains are made up of carbohydrates, and those carbohydrates are converted into glucose (a type of sugar) in our system which produces energy and helps our body to function, and is also used to perform various other tasks in our body. And any glucose that is not consumed as energy is stored as fat in our body. This shows that how modern diet is affecting our health and why the Paleo diet is so much important for us.